Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation
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چکیده
منابع مشابه
Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation
BACKGROUND Neuropathic pain is a global clinical problem; nevertheless, nerve injury treatment methods remain limited. Olanzapine has antinociceptive and anti-nueropathic properties; however, its preventive effects have not been assessed in nerve injury models. METHODS We prepared a partial sciatic nerve ligation (Seltzer model) or sham-operated model in male Sprague-Dawley rats under isoflur...
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Nerve injury can result in neuropathic pain, which persists after the injury and may occur after healing is completed. The long-term central reorganization associated with neuropathic pain has been previously studied in animal models. The immediate effects of nerve injury on central representation, however, are poorly understood. We examined the population response properties of closely neighbo...
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ژورنال
عنوان ژورنال: The Korean Journal of Pain
سال: 2015
ISSN: 2005-9159,2093-0569
DOI: 10.3344/kjp.2015.28.3.185